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- 1692 – First Spanish period: A Spanish royal cédula instructs the Conde de Galve to begin a detailed examination of Pensacola Bay.
- 2007 – A referendum is held on increasing the sales tax in Escambia County by one half-cent in order to fund primary healthcare for uninsured residents.
- 2008 – Baptist Health Care announces a $330 million expansion, later canceled, that would have included the purchase of West Florida Hospital.
- 2016 - Country music artist Brantley Gilbert performs in concert at The Wharf Amphitheater in Orange Beach.