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The population of Pensacola in 1821 was 695.
- July 17 – U.S. General Andrew Jackson accepts the transfer of Florida from Spain to the United States in Plaza Ferdinand VII and installs a provisional capital in Pensacola
- July 18 – U.S. General Andrew Jackson creates the Pensacola Police Department by appointing a city constable
- August 18 – The first issue of The Floridian is published.
- December 7 – First Methodist Church is established