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Mayes died on [[February 1]], [[1915]], in Pensacola. Listed cause of death was Facial Erysipelas complicated with Pleurisy. This was derived from an infected cut from a visit to the barber. Approximately 13 years later, the penicillin would be discovered that could have saved him. At the time of his death, he was also part owner of the ''Meridian Dispatch'', a newspaper in Mississippi.